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ea0026p301 | Pituitary | ECE2011

Patients with active acromegaly (AA) have less hepatic triglyceride than normal subjects using proton magnetic resonance spectroscopy (1H MRS)

McGlynn Stephen , Morris Tim , Higham Claire , Williams Steve , Trainer Peter

A decrease in insulin sensitivity (IS) is associated with increasing visceral adiposity. An inverse correlation has been demonstrated between Intramyo-(IMTG) and intrahepatocellular triglyceride (HCTG) concentrations and IS. Patients with AA have reduced IS but IMTG and HCTG content has not been studied.Eight patients with AA (IGF-I >ULN, median 1.83×ULN (range1.164.38) ((6 M), median age 39.5 (range 2366) years, median BMI 30.6(23.5...

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ea0034p308 | Pituitary | SFEBES2014

Inhibition of lipolysis improves peripheral and hepatic insulin sensitivity and restores first phase insulin response in patients with acromegaly

McGlynn Stephen J , Bluck Les , Salgin Burak , Trainer Peter J , Williams Steve , Higham Claire E

Acromegaly causes impaired insulin sensitivity and reduced fat mass. Using acipimox to block lipolysis, the impact of free fatty acids (FFA) on insulin sensitivity in active acromegaly was investigated. 1H MRS was used to quantify triglyceride (TG) content of liver and muscle.Methods: 6 patients with active acromegaly (AA) (5M, age 59 (3470), IGF-I (ng/ml) (median (range)) (452 (3421002)) were studied on 2 visits; (i) baseline (BL)...

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Endocrine Abstracts

Patients with active acromegaly (AA) have less hepatic triglyceride than normal subjects using proton magnetic resonance spectroscopy (1H MRS)

Inhibition of lipolysis improves peripheral and hepatic insulin sensitivity and restores first phase insulin response in patients with acromegaly

BiosciAbstracts